LIPOSOMA OFFERS DISTINCTIVE ADVANCED LIPID FORMULATIONS
For many years, LIPOSOMA has been gathering data from specialist scientific research into liposomes, lipids, pharmacology, and liposomal vitamin supplements (‘nutraceuticals’). Next to that, LIPOSOMA manufactures alternative advanced lipid formulations like nanostructured lipid carriers (NLCs) for poorly soluble lipophilic compounds and lipid nanoparticles (LNPs) to encapsulate nucleic acids. What sets us at LIPOSOMA apart in the field of lipid-based formulation is the research track record of our team. Our experts have worked in clinical development of liposomal products for parenteral administration, which require the highest quality standards.
We create lipid-based nonoparticles that genuinely consist of phospholipid vesicles, rather than emulsions containing phospholipids as surfactants. We also ensure our active ingredients are truly encapsulated inside the vesicles rather than just present among (and mostly outside) the liposomes. And every day in our own laboratories, we carry out more research into ‘ultra-small’ liposome technologies. Our ground-breaking research, objectified working processes, and state-of-the-art equipment all mean that we are able to develop distinctive lipid-based formulations and products.
LIPOSOMAL PRODUCT MANUFACTURING QUALITY
Our liposomal products always meet the highest quality standards. The active substance is held within the liposomal vesicle itself or in the double layer of the phospholipid membrane. In fact, our liposomes are optimised to such an extent that they can pass undamaged through the stomach and digestive tract. The ultra-small lipid vesicles also remain entirely intact during storage. Our liposomal excellence expands to formulations specifically designed for parenteral administration. Our liposome technology is based on numerous scientific research studies.
We use high-end Avestin equipment that enables us not only to homogenise liposomes, but also to ‘extrude’ them. Extrusion is a process which involves forcing ultra-small lipid suspensions through a membrane that has a fixed pore size. All the resulting liposomal vesicles then have similarly small dimensions, which improves the stability of the liposome formulation. Thanks to its improved stability, the product can then be stored intact for longer periods. We are always happy to advise you on the nano dimensions of the most appropriate pore size.
SUPERIOR LIPOSOMAL PRODUCTS
LIPOSOMA liposome products are superior in seven ways:
- They are comprised of genuine phospholipid bi-layered vesicles which contain the active substance.
- The active substance is only found within the liposomal vesicle or bi-layered membrane, and not outside it.
- Our liposomal products are optimised for oral ingestion and/or parenteral administration.
- We can produce custom liposomal formulations for any active substance, including in the fields of cosmetics and diagnostics.
- Every liposome has unique specifications and is subject to stringent quality control.
- Our liposomes are guaranteed to retain their quality during storage.
- Our liposomes retain their efficacy throughout their storage period.
OTHER ADVANCED LIPID FORMULATIONS
Next to liposome technology, LIPOSOMA Research & Development team has built up strong expertise in the manufacturing of other advanced lipid formulations. For food supplements that require a high encapsulation efficiency, NLCs offer an advantage above liposome technology. NLCs can also hold very poorly soluble ingredients, that tend to precipitate, in amorphous phase, hereby increasing the absorption and bioavailability of the active ingredients. Read more about NLCs here.
NUCLEIC ACID CONTAINING LIPID NANOPARTICLES
LIPOSOMA has extended its portfolio by manufacturing LNPs which are specifically designed to encapsulate nucleic acids, like mRNA, siRNA and DNA. By using specific charged phospholipids these LNPs protect the nucleic acid and efficiently transfect cells in vivo and in vitro. The nucleic acid is delivered intracellular to modulate gene expression in the target cells or to induce a robust immune response. The manufacturing is controlled by millifluidics and extensive batch analysis ensures an outstanding quality control of the particles. Read more about LNPs here.